Hydrazino-type radionuclide chelators having an N.sub.3 S configuration

A compound of the general formula:

• ##STR4## wherein R.sup.1 is H or a sulfur proteoting group;
• R.sup.2 and R.sup.3 are seleoted independently from H;
• carboxyl;
• lower alkyl;
• and lower alkyl substituted with a group seleoted from hydroxyl, sulfhydryl, halogen, oarboxyl and aminooarbonyl;
• R.sup.4 and R.sup.7 are each H;
• R.sup.5 and R.sup.6 are seleoted independently from H;
• carboxyl;
• lower alkyl;
• lower alkyl substituted with a group seleoted from hydroxyl, sulfhydryl, halogen, carboxyl, lower alkoxycarbonyl and aminocarbonyl;
• and an alpha carbon side ohain of any amino aoid other than proline;
• R.sup.8 is seleoted from H, carboxyl, lower alkyl and lower alkyl substituted with hydroxyl, carboxyl or halogen;
• and
• R.sup.9 and R.sup.10 together form a 5- or 6-membered, saturated or unsaturated heterocyclic ring which is optionally fused to another 5- or 6-membered saturated or unsaturated, heterooyolio or carbocyolio ring wherein either ring is optionally substituted with a group seleoted from halogen, alkyl, hydroxyalkyl, carboxyl, carboxyalkyl, carboxyalkylthio, thiooyanato, amino, hydrazino and a oonjugating group for ooupling a targeting moleoule to said either ring.