US 5,658,956 A · Bioadhesive-wound healing compositions and methods for preparing and using same

Abstract

The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic bioadhesive-wound healing compositions may further comprise medicaments such as antiviral agents, antikeratolytic agents, anti-inflammatory agents, antifungal agents, antibacterial agents, immunostimulating agents, and the like. The bioadhesive-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the bioadhesive-wound healing compositions and the pharmaceutical products in which the compositions may be used.

Claims32

Dependent claims

A therapeutic bioadhesive-wound healing composition which comprises a therapeutically effective amount of a bioadhesive agent and a wound healing composition, wherein the wound healing composition comprises:

(a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
(b) an antioxidant;
and
(c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the resuscitation of injured mammalian cells;
wherein components a, b, and c are present in amounts sufficient to synergistically enhance wound healing.

2 more elements

An augmented bioadhesive-wound healing composition which comprises:

(A) a therapeutic bioadhesive-wound healing composition which comprises:
(1) a therapeutically effective amount of a bioadhesive agent;
and
(2) a wound healing composition which comprises:
(a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
(b) an antioxidant;
and
(c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the repair of cellular membranes and resuscitation of mammalian cells;
wherein components a, b, and c are present in amounts sufficient to synergistically enhance wound healing;
and,
(B) a medicament useful for treating wounds.

8 more elements

Dependencies are inferred from the claim text.

Bioadhesive-wound healing compositions and methods for preparing and using same

Life of this patent

Bioadhesive-wound healing compositions and methods for preparing and using same

Life of this patent

Abstract

Claims32