Nucleic acid encoding transcription factor p300 and uses of p300
AssigneeDana-Farber Cancer Institute, Inc.
InventorsRichard Eckner, Mark Ewen, David Livingston
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Abstract
The invention features an isolated nucleic acid hybridizable with the complement of the coding strand nucleic acid sequence presented in SEQ ID NO:1, and encoding a protein that is necessary for adenovirus transformation of a mammalian cell. The encoded protein, p300, cooperates with adenovirus E1A (Early-region 1A) proteins to establish the transformed state.
Claims26
An isolated nucleic acid encoding a human p300 polypeptide having the amino acid sequence of SEQ ID NO:2.
A nucleic acid probe comprising 1 nucleotides that hybridizes under stringent conditions with a region of the nucleotide sequence of SEQ ID NO:1.
An isolated nucleic acid encoding amino acids 346-415 of SEQ ID NO:2.
An isolated nucleic acid encoding amino acids 1070-1134 of SEQ ID NO:2.
An isolated nucleic acid encoding amino acids 1162-1452 of SEQ ID NO:2.
An isolated nucleic acid encoding amino acids 1638-1807 of SEQ ID NO:2.
An isolated nucleic acid encoding amino acids 1572-1818 of SEQ ID NO:2.
An isolated acid encoding amino acids 1868-1921 of SEQ ID NO:2.
An isolated nucleic acid encoding amino acids 1921-2023 of SEQ ID NO:2.
An isolated nucleic acid encoding amino acids 2023-2107 of SEQ ID NO:2.
An isolated nucleic acid encoding amino acids 2107-2283 of SEQ ID NO:2.
An isolated nucleic acid encoding a polypeptide having the amino acid sequence of SEQ ID NO:2, except that amino acids 346-415 are deleted.
An isolated nucleic acid encoding a polypeptide having the amino acid sequence of SEQ ID NO:2, except that amino acids 1070-1134 are deleted.
An isolated nucleic acid encoding a polypeptide having the amino acid sequence of SEQ ID NO:2, except that amino acids 1162-1452 are deleted.
An isolated nucleic acid encoding a polypeptide having the amino acid sequence of SEQ ID NO:2, except that amino acids 1638-1807 are deleted.
An isolated nucleic acid encoding a polypeptide having the amino acid sequence of SEQ ID NO:2, except that amino acids 1572-1818 are deleted.
An isolated nucleic acid encoding a polypeptide having the amino acid sequence of SEQ ID NO:2, except that amino acids 1737-1809 are deleted.
An isolated nucleic acid encoding a polypeptide having the amino acid sequence of SEQ ID NO:2, except that amino acids 1737-1836 are deleted.
Dependencies are inferred from the claim text.