Process for the sterilization of biological compositions using UVA1 irradiation
AssigneeNew York Blood Center, Inc.
InventorsHenrietta Margolis-Nunno, Ehud Ben-Hur, Bernard Horowitz
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Abstract
An improvement in a process for inactivating extracellular and intracellular viruses in a platelet containing composition is presented. The improvement in the process comprises adding a sensitizer to the platelet containing composition and irradiating the composition containing the sensitizer with UVA1 in the absence of UVA2 for a period of time sufficient to inactivate the viruses while retaining the functionality of the platelet containing composition. A quencher or mixture of quenchers of type I and type II photodynamic reactions may be advantageously added to the composition prior to irradiation.
Claims10
In a process for treating an extracorporeal blood platelet-containing composition to inactivate an extracellular or intracellular virus that may be present therein, said process comprising the steps of adding an irradiation sensitizer to said composition and then subjecting the resultant composition to a virucidally effective amount of irradiation, wherein the improvement comprises utilizing as the source of said irradiation a source that emits a virucidally effective amount of UVA1 irradiation in the absence of UVA2 irradiation.
Dependencies are inferred from the claim text.