Electrochemical sensors
AssigneeMedisense, Inc.
InventorsMurdo Black, Long Lin, James Guthrie
Life of this patent
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Abstract
Erythrocyte exclusion membranes suited for test strips of electrochemical sensors have a porous matrix and a mobile erythrocyte aggregating agent. The membranes typically comprise a water-insoluble hydrophobic polymer incorporating a hydrophilic polymer and with the erythrocyte aggregating agent. Such membranes can have a pore size which is several times larger than the diameter of erythrocytes, and allow rapid passage of plasma by holding back the erythrocytes as rouleaux at the surface of the membrane. The membranes are preferably made by forming in situ on a test strip using spray casting.
Claims29
An erythrocyte exclusion membrane for a sensor, said membrane comprising a porous polymeric matrix including a water-insoluble hydrophobic polymer and a water-soluble hydrophilic polymer in said matrix, wherein said porous matrix comprises pores of pore diameters in the range of 1 to 15 .mu.m, said membrane further comprising a water-soluble erythrocyte aggregating agent.
A test strip for an electrochemical sensor for contact with whole blood in order to effect an electrochemical measurement, said test strip having an exclusion membrane in the form of a porous polymeric membrane, said membrane comprising a porous polymeric matrix including a water-insoluble hydrophobic polymer and a water-soluble hydrophilic polymer, wherein said porous matrix comprises pores of pore diameters in the range of 1 to 15 .mu.m, said membrane further comprising a water-soluble erythrocyte aggregating agent.
Dependencies are inferred from the claim text.