Oral vaccine comprising anti-idiotypic antibody to chlamydia glycolipid exoantigen and process
AssigneesThe Johns Hopkins University, University of Massachusetts
InventorsAlex Bruce MacDonald, Judith A. Whittum-Hudson, William Mark Saltzman
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Abstract
A genus specific chlamydia oral or injectable vaccine is provided which comprises an anti-idiotype antibody capable of producing in an animal an anti-idiotypic antibody or Fab fragment thereof enclosed in microspheres formed of a pharmacologically acceptable polymer is capable of producing in an animal an anti-anti-idiotypic immune response (serum antibody, secretory antibody or T-cell responsee) which recognizes a glycolipid exoantigen (GLXA) of chlamydia. The oral or injectable vaccine is produced from an idiotypic antibody to GLXA which, in turn, is utilized to produce the anti-idiotypic antibody.
Claims15
An oral vaccine for administration to an animal in an amount sufficient to effect immunization against chlamydia which comprises microspheres having a solid matrix formed of a pharmacologically acceptable polymer containing a biologically active composition, wherein said composition is selected from the group consisting of a monoclonal anti-idiotypic antibody, a Fab fragment of said monoclonal anti-idiotypic antibody, a (Fab).sub.2 fragment of said monoclonal anti-idiotypic antibody, and mixtures thereof, wherein said monoclonal anti-idiotypic antibody, said Fab fragment and said (Fab).sub.2 fragment induces in an animal anti-anti-idiotypic antibody which binds an epitope on genus specific chlamydia glycolipid exoantigen (GLXA).
The process for immunizing an animal against chlamydia infection which comprises orally administering to said animal a biologically active composition which comprises microspheres having a solid matrix formed of a pharmacologically acceptable polymer, wherein said composition is selected from the group consisting of a monoclonal anti-idiotypic antibody, a Fab fragment of said monoclonal anti-idiotypic antibody, a (Fab).sub.2 fragment of said monoclonal anti-idiotypic antibody, and mixtures thereof, and wherein said monoclonal anti-idiotypic antibody, said Fab fragment and said (Fab).sub.2 fragment induces in an animal anti-anti-idiotypic antibody which binds an epitope on genus specific chlamydia glycolipid exoantigen (GLXA) in an amount sufficient to effect immunization against chlamydia infection.
Dependencies are inferred from the claim text.