Partial liquid breathing of fluorocarbons
AssigneeAlliance Pharmaceutical Corp.
InventorsNicholas Simon Faithfull, Jeffry Greg Weers
Life of this patent
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Abstract
The present invention includes a method for treating a patient in need of facilitated oxygen delivery through the lungs, additional lung surfactant, removal of material from inside the lung, or inflation of collapsed portions of the lung, comprising the step of introducing into the lung of the patient an effective therapeutic amount of a fluorocarbon liquid, the amount not exceeding the functional residual capacity of the lung of the patient upon exhalation taking into account any positive and expiratory pressure applied to the patient's lung. The method may also comprise the additional step of providing an oxygen-containing breathing gas to the patient while the fluorocarbon liquid is in the lung.
Claims44
A method of facilitating oxygen delivery through the lung of a patient comprising the steps of:
- administering to the lung of the patient an effective oxygen delivery-facilitating amount of a fluorocarbon liquid having an equilibrium coefficient of spreading which is a positive number, said amount of administered fluorocarbon liquid not exceeding 35% of the functional residual capacity of the lung of the patient upon exhalation taking into account any positive or negative expiratory pressure applied to said patient's lung;
- and
- introducing a breathing gas into the lung wherein said introduced breathing gas physically admixes with and oxygenates said fluorocarbon liquid within the lung.
A method for the pulmonary administration of a pharmacologic agent to a patient comprising:
- administering to the lung of the patient an effective therapeutic amount of a pharmacologic agent dispersed in a volume of fluorocarbon liquid having an equilibrium coefficient of spreading which is a positive number, said administered volume of fluorocarbon liquid not exceeding 35% of the functional residual capacity of the lung of the patient upon exhalation taking into account any positive or negative expiratory pressure applied to said patient's lung;
- and
- introducing a breathing gas into the lung wherein said introduced breathing gas physically admixes with and oxygenates said fluorocarbon liquid within the lung.
A method of facilitating oxygen delivery through the lung of a patient comprising the steps of:
- administering to the lung of the patient an effective oxygen delivery-facilitating amount of a non-brominated fluorocarbon liquid having an equilibrium coefficient of spreading which is a positive number, said amount of administered non-brominated fluorocarbon liquid not exceeding the functional residual capacity of the lung of the patient upon exhalation taking into account any positive or negative expiratory pressure applied to said patient's lung;
- and
- introducing a breathing gas into the lung wherein said introduced breathing gas physically admixes with and oxygenates said non-brominated fluorocarbon liquid within the lung.
A method for removing material from the lung of a patient comprising the steps of:
- administering to the lung of the patient an effective material displacing amount of a non-brominated fluorocarbon liquid having an equilibrium coefficient of spreading which is a positive number, said amount of administered non-brominated fluorocarbon liquid not exceeding the functional residual capacity of the lung of the patient upon exhalation taking into account any positive or negative expiratory pressure applied to said patient's lung wherein the administered non-brominated fluorocarbon liquid displaces material inside the lung;
- introducing a breathing gas while the non-brominated fluorocarbon liquid is in the lung;
- and
- removing said non-brominated fluorocarbon liquid together with at least a portion of the displaced material from the lung.
A method of facilitating oxygen delivery through the lung of a patient comprising the steps of:
- administering to the lung of the patient an effective oxygen delivery-facilitating amount of a fluorocarbon liquid having an equilibrium coefficient of spreading which is a positive number and comprising fluorocarbons selected from the group consisting of bis(F-alkyl) ethanes, cyclic fluorocarbons, fluorinated amines, fluorocarbon esters, fluorocarbon thioesters, perfluoroalkylated ethers, perfluoroalkylated polyethers and fluorocarbon-hydrocarbon compounds, said amount of administered fluorocarbon liquid not exceeding the functional residual capacity of the lung of the patient upon exhalation taking into account any positive or negative expiatory pressure applied to said patient's lung;
- and
- introducing a breathing gas into the lung wherein said introduced breathing gas physically admixes with and oxygenates said non-brominated fluorocarbon liquid within the lung.
Dependencies are inferred from the claim text.