Boronated metalloporphyrine and therapeutic methods
AssigneeThe Regents of the University of California
InventorsStephen B. Kahl, Myoung-Seo Koo
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Abstract
Carborane substituted porphyrin compounds complexed with a metal or transition metal have a variety of therapeutic uses. These compounds have been found, for example, selectively to inhibit viral aspartyl proteases. The transition metal complexes are useful both therapeutically in BNCT (boron neutron capture therapy) as well as for MR contrast enhancement. Particularly preferred compounds in accordance with the invention use the dipotassium salt of 2,4-bis-[.alpha.,.beta.-(1,2-dicarbaclosododecaborane carboxy)ethyl]deuteroporphyrin, which is complexed with a metal or a transition metal. These compounds are well solubilized in water, and are suitable for oral administration.
Claims8
A porphyrin-based compound having the structure:
- ##STR8## where R.sup.3 is a carborane and R.sup.2 is an alkyl or an aryl having 1 to about 7 carbon atoms, or a physiologically acceptable salt thereof.
A biologically active, porphyrin-based compound having the structure:
- ##STR9## where each of R and R.sup.1 is selected from --H, --OH, or ##STR10## and at least one of R and R.sup.1 is ##STR11## R.sup.3 is a carborane, R.sup.2 is --H, an alkyl, or an aryl, having 1 to about 7 carbon atoms, or a physiologically acceptable salt thereof, and R.sup.4 is manganese, copper or cobalt.
Dependencies are inferred from the claim text.