Oral immunization by transgenic plants
AssigneeWashington University
InventorsRoy Curtiss, III, Guy A. Cardineau
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Abstract
The invention is directed to transgenic plants expressing colonization and/or virulence antigens specified by genes from pathogenic microorganisms. It is also directed to the use of such transgenic plants for oral immunization of humans and other animals to elicit a secretory immune response which inhibits colonization of or invasion by such pathogenic microorganisms through a mucosal surface of humans or other animals.
Claims5
A method of making a composition suitable for eliciting a secretory immune response in a human or other animal, said composition comprising a transgenic plant or transgenic plant tissue obtained from said transgenic plant which comprises and expresses a DNA sequence coding for an antigen or antigenic determinant of a pathogenic microorganism, said antigen or antigenic determinant being capable of eliciting a secretory immune response upon oral administration of said transgenic plant or said transgenic plant tissue, wherein the method comprises the step of mixing said transgenic plant or said transgenic plant tissue with a food substance.
Dependencies are inferred from the claim text.