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US 5,654,008 AGranted
Preparation of biodegradable microparticles containing a biologically active agent
AssigneeAlkermes Controlled Therapeutics Inc. II
InventorsPaul F. Herbert, Azar M. Hazrati
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Abstract
A process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent. A first phase, comprising the active agent and the polymer, and a second phase are pumped through a static mixer into a quench liquid to form microparticles containing the active agent. Preferably, a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer.
Claims21
A method of preparing microparticles, comprising:
- preparing a first phase, said first phase comprising an active agent and a polymer;
- preparing a second phase;
- preparing a quench liquid;
- and
- pumping said first phase and said second phase through a static mixer into said quench liquid thereby forming microparticles containing said active agent.
2 more elements
A method of preparing microparticles, comprising:
- preparing a first phase, said first phase comprising an active agent and a polymer;
- preparing a second phase, wherein said second phase is free from solvents for said polymer;
- preparing a quench liquid;
- and
- pumping said first phase and said second phase through a static mixer into said quench liquid thereby forming microparticles containing said active agent.
2 more elements
Dependencies are inferred from the claim text.