Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same

A heterofunctional cellular immunological product comprising at least two T cell specific binding ligands covalently linked together,

• wherein the T cell specific binding ligands are derived from different molecules, and
• wherein one of said T cell specific binding ligands is a peptide which binds to a specific class or subclass of T cells selected from the group consisting of helper T cells, suppressor T cells and cytotoxic T cells and modulates T cell activity,
• wherein when said T cell specific binding ligand which binds to a specific class or subclass of T cells is derived from an MHC molecule, such consists of the non-polymorphic region of the MHC molecule;
• and
• another of said T cell specific binding ligands is an antigenic peptide associated with disease or a causative agent of disease, or an epitope thereof, and
• wherein said product is about 20 to 100 amino acids in length.