Ulcer prevention and treatment composition
AssigneeFuisz Technologies Ltd.
InventorRichard C. Fuisz
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Abstract
Anti-ulcer compositions are disclosed having therapeutic agents dispersed in a soluble matrix formed by melt spinning the therapeutic agent with a carrier and hydrogel. Methods of treating ulcer-bearing tissue and preparing the matrix are also disclosed. One embodiment includes use of gastric irritating bio-affecting agents in which case the composition is preventative as well as therapeutic.
Claims35
An anti-ulcer composition having rapid delivery and enhanced adherence to ulcer-bearing tissue comprising:
- a solid matrix having suspended therein an anti-ulcer medicament, said matrix formed by flash-flow melt-spinning a mixture of
- i) a melt-spinnable carrier material present in an amount sufficient to form a flash-flow melt-spun matrix when said anti-ulcer medicament is dispersed therein;
- ii) an anti-ulcer medicament present in an amount sufficient to achieve a therapeutic effect;
- and
- iii) a hydrogel in addition to said carrier material, said hydrogel being selected from the group consisting of gums, cellulose, pectins, gelatin, polycarbophil, alginate and mixtures thereof to provide mucosal adherence.
An anti-ulcer medication comprising:
- a) an anti-ulcer medicament dispersed in a first matrix formed by subjecting to flash-flow condition a first feedstock comprising said medicament and a mixture comprising a saccharide carrier material and a hydrogel selected from the group consisting of gums, celluloses, pectins, gelatin, polycarbophil, alginate and mixtures thereof to provide mucosal adherence;
- b) an antacid agent dispersed in a second matrix formed by subjecting flash-flow conditions a second feedstock comprising said antacid and a carrier material comprising a saccharide.
A pharmaceutical composition having rapid delivery and enhanced adherence to mucosal tissue comprising:
- a solid matrix having suspended therein a medicament, said matrix formed by flash-flow melt-spinning a mixture of
- i) a melt-spinnable carrier comprising a saccharide present in an amount sufficient to form a flash-flow melt-spun matrix when said medicament is dispersed therein;
- ii) a medicament present in an amount sufficient to achieve a therapeutic effect;
- and
- iii) a hydrogel in addition to said carrier, said hydrogel being selected from the group consisting of gums, celluloses, pectins, gelatin, polycarbophil, alginate and mixtures thereof to provide mucosal adherence properties.
Dependencies are inferred from the claim text.