US 5,650,435 AGranted

Modulation of inflammation related to columnar epithelia

OwnerJames L. Madara, Charles N. Serhan +1inventors

InventorsJames L. Madara, Charles N. Serhan, Sean P. Colgan

Life of this patent

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Abstract

This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods for screening for compounds useful in preventing columnar epithelial inflammation.

Claims27

Dependent claims

A method for restoring transportation of fluids, electrolytes, or nutrients by a columnar epithelium in a subject to a normal, homeostatic level, comprising administering to the subject an effective anti-diuretic amount of a pharmaceutical composition comprising a lipoxin A.sub.4 compound and a pharmaceutically acceptable carrier.

Dependencies are inferred from the claim text.

Facts

Application: 08/268,049Filed 29 Jun 1994 · continuation in part
Priority: 1 Apr 1991
Granted: 22 Jul 1997
Term ends: Not estimatedThe source records don’t support an estimate.

Classification36 codes

G01N 33/5088
Supracellular entities, e.g. tissue, organisms: of vertebrates
A61K 31/20
Carboxylic acids, e.g. valproic acid: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
A61K 31/215
Esters, e.g. nitroglycerine, selenocyanates: of carboxylic acids
A61K 31/216
Of carboxylic acids: of acids having aromatic rings, e.g. benactizyne, clofibrate

Family

Serial677,388Parent of this continuation-in-part · filed 1 Apr 1991
Serial748,349Parent of this continuation-in-part · filed 22 Aug 1991
Serial84,311Parent of this continuation-in-part · filed 29 Jun 1993
US 5,650,435 AThis patent

From the US filing history. Foreign family members aren’t listed.

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