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US 5,650,234 AGranted
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
AssigneeSurface Engineering Technologies, Division of Innerdyne, Inc.
InventorsEric Kurt Dolence, Chen-Ze Hu, Ray Tsang, Clifton G. Sanders, Shigemasa Osaki
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Abstract
Several poly(ethylene glycol) mixed carbonates and their preparation are closed. These carbonates are synthesized by conversion of polyethylene glycol first to the chloroformate then by reaction with the hydroxyl group of N-hydroxybenzotriazole or 2-hydroxypyrimidine or N-hydroxy-2-pyrrolidinone. These mixed carbonate analogs smoothly react with amino groups in aminoglycans and protein and amino containing surfaces to form stable, hydrolysis resistant carbamate linkages.
Claims21
A compound of the formula:
- ##STR6## wherein R.sub.1 is selected from an N-benzotriazole group, an N-2-pyrrolidinone group, or an 2-oxypyrimidine group;
- R.sub.2, R.sub.3 and R.sub.4 are independently selected alkylene groups of about 2 to about 3 carbon atoms and may be the same or different;
- R.sub.5 is selected from hydrogen, methyl, a carbonyloxy-N-benzotriazole group, a carbonyloxy-N-2-pyrrolidinone group, and a carbonyl-2-oxypyrimidine group;
- a is an integer from 1 to 1000 and each of b and c is an integer from 0 to 1000, where a+b+c is an integer from 3 to 1000.
1 more element
Dependencies are inferred from the claim text.