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US 5,648,387 AGranted
Carboxyalkylethers, formulations, and treatment of vascular diseases
AssigneeWarner-Lambert Company
InventorsCharles Larry Bisgaier, Paul Leroy Creger, Alan Robert Saltiel, Sherrie Rae Tafuri
Life of this patent
Estimating the term…
Abstract
Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
Claims21
A compound of the formula ##STR13## wherein n and m independently are integers from 4 to 5;
- R.sub.1, R.sub.2, R.sub.3, and R.sub.4 independently are C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, and R.sub.1 and R.sub.2 together with the carbon to which they are attached, and R.sub.3 and R.sub.4 together with the carbon to which they are attached, independently can complete a carbocyclic ring having from 3 to 6 carbons;
- Y.sub.1 and Y.sub.2 independently are COOH, CHO, tetrazole, and COOR.sub.5 where R.sub.5 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl;
- and where the alkyl, alkenyl, and alkynyl groups may be substituted with one or two groups selected from halo, hydroxy, C.sub.1 -C.sub.6 alkoxy, and phenyl, and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.