Process for the production of microcapsules
AssigneeSchwarz Pharma AG
InventorsBruno Gander, Hans Peter Merkle
Life of this patent
Estimating the term…
Abstract
A method for the production of microcapsules embedded with pharmaceuticals, peptides, proteins, enzymes and vaccines, which uses biodegradable solvents, and microcapsules free of toxic residual solvents is described. The microcapsules are obtained by spraying of a solution, suspension or water-in-oil dispersion of active materials and biodegradable polymers.
Claims24
A method of manufacturing microcapsules containing one or more biodegradable polymers and at least one active material, which method comprises:
- (a) dissolving the biodegradable polymer(s) in a non-toxic biodegradable solvent which is selected from esters of a C.sub.1 -C.sub.5 -alcohol and a C.sub.1 -C.sub.5 -monocarboxylic acid;
- (b) incorporating at least one active material into the solution of the biodegradable polymer(s) obtained in step (a) either in the form of a solution of said active material in said biodegradable solvent;
- or in the form of a micronized powder of said active material, or in the form of a solution of said active material in an aqueous medium, and
- (c) spray drying the solution, suspension or water-in-oil dispersion obtained in step (b).
A method of manufacturing microcapsules comprising:
- (a) dissolving one or more biodegradable polymers in a non-toxic biodegradable solvent which is selected from esters of a C.sub.1 -C.sub.5 -alcohol and a C.sub.1 -C.sub.5 -monocarboxylic acid to form a first solution;
- (b) dissolving an active material in a non-toxic biodegradable solvent which is selected from esters of a C.sub.1 -C.sub.5 -alcohol and a C.sub.1 -C.sub.5 -monocarboxylic acid to form a second solution;
- (c) combining the first solution with the second solution to obtain a substrate solution and,
- (d) spray drying the substrate solution.
A method of manufacturing microcapsules comprising:
- (a) dissolving one or more biodegradable polymers in a non-toxic biodegradable solvent which is selected from esters of a C.sub.1 -C.sub.5 -alcohol and a C.sub. -C.sub.5 -monocarboxylic acid to form a polymer solution;
- (b) suspending an active material mechanically or by means of ultrasound in the polymer solution to obtain a substrate suspension, and
- (c) spray drying the substrate suspension.
A method of manufacturing microcapsules comprising:
- (a) dissolving one or more biodegradable polymers in a non-toxic biodegradable solvent which is selected from esters of a C.sub.1 -C.sub.5 -alcohol and a C.sub.1 -C.sub.5 -monocarboxylic acid to form a polymer solution;
- (b) dissolving an active material in an aqueous medium to form an aqueous active material solution;
- (c) mixing the aqueous active material solution with the polymer solution mechanically or with ultrasound to obtain substrate water-in-oil dispersion, and
- (d) spray drying the substrate water-in-oil dispersion.
Dependencies are inferred from the claim text.