Anti-protozoan methods

A method of treating protozoan infections comprising the step of administering a composition comprising an active agent selected from the group consisting of bactericidal/permeability-increasing (BPI) holoprotein, N-terminal fragments thereof commencing at residue 1 and ending at about residue 193 to 199, dimeric forms thereof, and rBPI.sub.21, at a dose of about 100 .mu.g/kg to about 100 mg/kg, to a mammalian subject infected with a protozoan species selected from the group consisting of Toxoplasma gondii, Leishmania species, Trypanosoma cruzi, Plasmodium vivax, Plasmodium falciparum, Plasmodium ovale and Plasmodium malariae.