Therapeutic antibody based fusion proteins
AssigneeOncogen
InventorsHenry Perry Fell, Jr., Margit Ann Gayle
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Abstract
The present invention relates to methods of providing a targeted, amplified antitumor immune response using antibody-based fusion proteins. More specifically, the invention relates to the use of antibody-based fusion proteins comprising an immunoglobulin portion capable of binding to a tumor antigen linked to a biologically active lymphokine. The immunoglobulin portion targets the fusion protein to the site of the tumor cells and the lymphokine portion stimulates the proliferation of immune T cells at the site of the tumor cells, thereby amplifying the anti-tumor immune response. In preferred embodiments of the invention, the immunoglobulin portion of the fusion protein is derived from the L6 monoclonal antibody and/or the lymphokine is interleukin-2.
Claims2
A method of increasing an antitumor immune response comprising exposing tumor cells, in the presence of immune effector cells, to an antibody-based fusion protein comprising a variable region of an immunoglobulin molecule capable of binding to an antigen on the surface of the tumor cell linked via peptide linkage to an IL-2 molecule capable of promoting lymphocyte proliferation.
Dependencies are inferred from the claim text.