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US 5,643,713 AGranted
Electrochemiluminescent monitoring of compounds
OwnerPam Liang, Mark T. Martin +1inventors
InventorsPam Liang, Mark T. Martin, Liwen Dong
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Abstract
Detectable compounds comprising a chemically-transformable first compound covalently linked to an electrochemiluminescent compound are provided. Such compounds are useful in processes and kits that monitor the status of the first compound and derive information from such monitoring.
Claims20
A detectable electrochemiluminescent compound useful for monitoring changes in compounds, comprising:
- (a) a chemically-transformable first compound covalently linked to an electrochemiluminescent compound;
- wherein
- (I) the first compound is a substrate capable of (i) being chemically transformed upon an interaction with at least one second compound which is an enzyme specific to said substrate;
- (ii) intramolecularly donating an electron to the electrochemiluminescent compound to cause the electrochemiluminescent compound to subsequently luminesce;
- and (iii) varying in its ability to effect such intramolecular donation of an electron before and after any interaction;
- and
- (II) upon the exposure of the detectable compound to electrochemical energy the first compound intramolecularly donates an electron to the electrochemiluminescent compound to cause the electrochemiluminescent compound to luminesce.
4 more elements
Dependencies are inferred from the claim text.