US 5,643,580 A · Biocompatible coating, medical device using the same and methods

Abstract

The invention involves using a plasma to functionalize a surface of medical devices such as catheters, particularly intracardial catheters, with covalently bound thermochemically reactive groups. The surface is further contacted with a bioactive agent, particularly antithrombogenic coatings, which is thermochemically covalently coupled to the reactive group to form a therapeutically effective coating. The selected bioactive agent is then covalently bound to the surface by thermochemical reaction with the surface reactive groups. In another embodiment, the functionalizing step comprises contacting the surface with a Langmuir-Blodgett film comprising an amphipathic compound and a bioactive agent and using a plasma to covalently crosslink the Langmuir-Blodgett film to the medical device surface and to the bioactive agent. Medical devices prepared by the subject methods are also provided.

Claims22

Dependent claims

A method for treating a surface of a medical device to inhibit thrombosis comprising steps:

functionalizing a surface of a medical device by contacting said surface with a low temperature plasma which surface is exposed to blood flow continuous with bodily blood circulation with a first reactive group, contacting said surface with an antithrombogenic agent capable of reacting with said first reactive group, and causing said antithrombogenic agent to react with said first reactive group to covalently bind said antithrombogenic agent to said surface to form a coating on said surface which coating is effective to inhibit the formation of thrombus when said surface is exposed to blood flow continuous with bodily blood circulation.

Dependencies are inferred from the claim text.

Biocompatible coating, medical device using the same and methods

Life of this patent

Biocompatible coating, medical device using the same and methods

Life of this patent

Abstract

Claims22