Immunization by inoculation of DNA transcription unit
AssigneesUniversity of Massachusetts Medical Center, St. Jude Children's Research Hospital
InventorsHarriet L. Robinson, Ellen F. Fynan, Robert G. Webster
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Abstract
This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antigen or antigens, thereby eliciting humoral or cell-mediated immune responses or both humoral and cell-mediated responses. The elicited humoral and cell-mediated immune responses can provide protection against infection by pathogenic agents, provide an anti-tumor responses, or provide contraception. The host can be any vertebrate, avian or mammal, including humans.
Claims19
A method of immunizing a vertebrate against an infectious agent, said method comprising administering to a vertebrate a DNA transcription unit comprising DNA encoding a hemagglutinin of the infectious agent operatively linked to a promoter region, whereby the vertebrate is protected from disease caused by the infectious agent.
A method of immunizing a vertebrate against an infectious agent, said method comprising administering to a mucosal surface of a vertebrate a DNA transcription unit comprising DNA encoding a hemagglutinin of the infectious agent operatively linked to a promoter region, in a physiologically acceptable carrier, whereby the vertebrate is protected from disease caused by the infectious agent.
A method of immunizing a vertebrate against influenza virus, said method comprising administering to a vertebrate a DNA transcription unit comprising DNA encoding an influenza virus antigen operatively linked to a promoter region, whereby the vertebrate is protected from disease caused by influenza virus.
A method of immunizing a vertebrate against influenza virus, said method comprising administering to a mucosal surface of a vertebrate a DNA transcription unit comprising DNA encoding an influenza virus antigen operatively linked to a promoter region, in a physiologically acceptable carrier, whereby the vertebrate is protected from disease caused by influenza virus.
Dependencies are inferred from the claim text.