Oral vaccine comprising antigen surface-associated with red blood cells
AssigneeThe University of Newcastle Research Associates Limited
InventorsGerald Toh Pang, Robert Llewellyn Clancy
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Abstract
Red blood cells or derivatives thereof such as ghost preparations can act as a potent carrier for orally administered antigens. Mucosal immunity in particular can be effectively induced against such viruses as influenza when adsorbed to chicken red blood cells and orally administered.
Claims13
An oral vaccine comprising an influenza antigen, wherein said influenza antigen is surface-associated with a red blood cell or a ghost preparation thereof, and wherein said vaccine elicits a mucosal immune response in mammals.
An oral vaccine comprising an influenza Type A antigen, wherein said influenza antigen is surface-associated with a red blood cell or a ghost preparation thereof, and wherein said vaccine elicits a mucosal immune response in mammals.
Dependencies are inferred from the claim text.