US 5,641,783 A · Substituted amino alcohol compounds

Abstract

Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocycle. R.sub.3 may be either hydrogen or C.sub.1-3. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.4 is a terminal moiety comprising a substituted or unsubstituted, oxidized or reduced ring system, the ring system having a single ring or two to three fused rings, a ring comprising from three to seven ring atoms. The disclosed compounds are effective agents to inhibit undesirable responses to cell stimuli.

Claims22

Dependent claims

A compound comprising a straight or branched aliphatic hydrocarbon structure of formula I:

##STR108## wherein:
n is an integer from one to four;
m is an integer from seven to twenty;
independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5, w being an integer from one to twenty and R.sub.5 being an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle;
or
jointly R.sub.1 and R.sub.2 form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hereto atom;
R.sub.3 is hydrogen or C.sub.1-3 ;
or
jointly one of R.sub.1 or R.sub.2 and R.sub.3 form a substituted or unsubstituted linking carbon chain, having from one to four carbon atoms, joining the O and N in a cyclic structure, an integer sum equal to n+ a number of carbon atoms in the linking carbon chain being less than six;
a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty;
and
R.sub.4 is a substituted or unsubstituted terminal, heterocyclic moiety having one five-to-six-membered ring or two five- to six-membered rings, (CH.sub.2).sub.m being attached to a nitrogen atom of the heterocyclic moiety, the compound including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof.

9 more elements

Dependencies are inferred from the claim text.

Substituted amino alcohol compounds

Life of this patent

Substituted amino alcohol compounds

Life of this patent

Abstract

Claims22