Fiber-optic detectors with terpolymeric analyte-permeable matrix coating
AssigneeAbbott Laboratories
InventorsLokanathan M. Iyer, Yanqun Zhao
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Abstract
The invention provides fiber-optic detectors with rapid response times for measuring analytes in aqueous solutions, including blood. The detectors, because of their size, accuracy, and sterilizability may be used in vitro. In a preferred embodiment, pellets comprising a unique, permeable terpolymer of methyl methacrylate, butyl acrylate and methacrylamidopropyltrimethylammonium chloride; and an indicator for an analyte are used as the detecting element of a fiber-optic sensor. Response times for pH testing are better than 150 seconds at t90%. The pellets are easily made by solvent casting techniques and failure rates are low.
Claims20
A fiber-optic blood analyte detector comprising:
- at least one fiber-optic filament with an end having a detecting element for immersion in blood to be analyzed, the detecting element comprising an analyte-permeable matrix for detecting analytes in said blood, the matrix comprising:
- (i) a terpolymer of methyl methacrylate, butyl acrylate and methacrylamidopropyltrimethylammonium chloride;
- and
- (ii) an indicator for analytes to be detected in blood;
- wherein said matrix has a permeability to the analytes that allows detection of pH at t90% in less than about 150 seconds.
A fiber-optic blood analyte detector comprising:
- at least one fiber-optic filament with an end having a detecting element for immersion in blood to be analyzed;
- the detecting element comprising an analyte-permeable matrix for detecting analytes in said blood, the matrix comprising a terpolymer comprising from about 85 to about 60 mole percent methyl methacrylate, from about 10 to about 25 mole percent butyl acrylate, and from about 5 to about 10 mole percent of methacrylarnidopropyltrimethylammonium chloride;
- and an indicator for analytes to be detected in blood.
A fiber-optic detector for detecting changes in the pH of blood, comprising:
- at least one fiber-optic filament with a detecting element at one end thereof for immersion in blood to be analyzed for pH;
- the detecting element comprising:
- (i) an analyte-permeable matrix comprising a terpolymer of from about 85 to about 60 mole percent methyl methacrylate, from about 10 to about 25 mole percent butyl acrylate, and from about 5 to about 10 mole percent methacrylamidopropyltrimethylammonium chloride;
- and
- (ii) an indicator sensitive to and changing light reflected therefrom in response to changes in hydrogen ion concentration, wherein said matrix has a permeability to hydrogen ions that allows detection of pH at t90% in less than about 150 seconds.
Dependencies are inferred from the claim text.