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AssigneeCiba-Geigy Corporation
InventorsJames M. Ligon, Dwight Steven Hill, John Andrew Ryals, Stephen Ting Lam, Philip E. Hammer
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The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
An isolated DNA molecule encoding one or more polypeptides required for the biosynthesis of pyrrolnitrin, wherein said DNA molecule has a nucleotide sequence selected from the following group:
An isolated DNA molecule encoding one or more polypeptides required in the biosynthetic pathway of pyrrolnitrin in a host, wherein said one or more polypeptides have amino acid sequences selected from SEQ ID NO's:
Dependencies are inferred from the claim text.