Prefilled, two-constituent syringe

A prefilled syringe system for separately storing a concentrated constituent and a liquid constituent and for subsequently mixing and dispensing a mixture of said constituents, said system comprising:

• a syringe barrel having a dispensing end with an inwardly directed, stationary, piercing cannula communicating through said dispensing end to accommodate the dispensing of fluid from said syringe barrel;
• a first, sealed, collapsible container that contains a first constituent at subatmospheric pressure and that is slidably disposed within said syringe barrel adjacent said stationary piercing cannula;
• a second, sealed, collapsible container that contains a liquid second constituent and that is slidably disposed within said syringe barrel spaced from said first container;
• a carrier that is slidably disposed within said syringe barrel between said first and second containers and that carries a double-ended, hollow, piercing needle having oppositely extending first and second ends for piercing said first and second containers, respectively;
• and
• a plunger slidably mounted within said syringe barrel for applying a force to said second container to sequentially (1) pierce said second container with said needle second end, (2) pierce said first container with said needle first end, (3) collapse said second container while discharging said liquid second constituent into said first container, (4) pierce said first container with said cannula, and (5) collapse said first container while dispensing the contents of said first container.

A prefilled syringe system comprising:

• a syringe barrel having a dispensing end with an inwardly directed, stationary, piercing cannula communicating through said dispensing end to accommodate the dispensing of fluid from said syringe barrel;
• a first, sealed, collapsible container that contains a first constituent at subatmospheric pressure and that is slidably disposed within said syringe barrel adjacent said stationary piercing cannula;
• a second, sealed, collapsible container that contains a liquid second constituent and that is slidably disposed within said syringe barrel spaced from said first container;
• a carrier that is slidably disposed within said syringe barrel between said first and second containers, that maintains separation between the said first and second containers and that carries a double-ended, hollow, piercing needle having oppositely extending first and second ends for piercing said first and second containers, respectively;
• and
• a plunger slidably mounted within said syringe barrel for applying a force to said second container.