Human oxalyl-CoA decarboxylase
AssigneesHuman Genome Sciences, Inc., The Institute for Genomic Res.
InventorsHenrik S. Olsen, Timothy A. Coleman, Mark D. Adams
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Abstract
A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.
Claims22
An isolated polynucleotide comprising a polynucleotide member selected from the group consisting of:
- (a) a polynucleotide having a sequence with least 95% identity to a polynucleotide coding sequence encoding amino acids 2 to 578 of SEQ ID NO:2;
- and
- (b) the complement of the polynucleotide of (a).
An isolated polynucleotide comprising a polynucleotide member selected from the group consisting of:
- (a) a polynucleotide having a sequence with at least 95% identify to the portion of a polynucleotide sequence encoding the same mature polypeptide encoded by the human cDNA in ATCC Deposit No. 75715;
- and
- (b) the complement of the polynucleotide of (a).
Dependencies are inferred from the claim text.