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US 5,635,606 AGranted
Method of binding and removing toxin A
AssigneeSynsorb Biotech, Inc.
InventorsLouis D. Heerze, Glen D. Armstrong
Life of this patent
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Abstract
This invention relates to treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD) and pseudomembranous colitis (PMC), using oligosaccharide compositions which bind C. difficile toxin A. More specifically, the invention concerns neutralization of C. difficile toxin A associated with CDAD.
Claims3
A method to bind and remove toxin A from a sample suspected of containing said toxin A, which method comprises:
- a) contacting said sample with an oligosaccharide sequence selected from the group consisting of
- .alpha.Gal(1-3).beta.Gal
- (1-2)
- .alpha.Fuc;
- .beta.Gal(1-4).beta.GlcNAc
- (1-2)
- .alpha.Fuc;
- .alpha.Gal(1-3).beta.Gal(1-4).beta.GlCNAc
- (1-2)
- .alpha.Fuc;
- .beta.Gal(1-4).beta.GlcNAc;
- .alpha.Gal(1-4).beta.Gal(1-4).beta.Glc;
- .alpha.NeuAc(2-6).beta.Gal(1-4).beta.Glc;
- .alpha.Gal(1-3).beta.Gal(1-4).beta.Glc;
- .beta.Gal(1-4).beta.Glc;
- (1-2)
- .alpha.Fuc;
- .alpha.Gal(1-3).beta.Gal(1-4).beta.Glc;
- (1-2)
- .alpha.Fuc;
- and
- .alpha.Gal(1-3).beta.Gal(1-3).beta.GlcNAc
- covalently attached to a solid, inert support through a non-peptidyl compatible linker arm, wherein said oligosaccharide sequence binds toxin A, under conditions wherein said toxin A is absorbed to said support;
- and
- b) separating the support containing the absorbed toxin A from the sample.
22 more elements
Dependencies are inferred from the claim text.