Beta-8 integrin subunit antibodies
AssigneeGenentech, Inc.
InventorsMatthew Moyle, John W. McLean
Life of this patent
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Abstract
The cDNA encoding a novel beta integrin subunit, called the beta-8 integrin subunit, has been isolated from rabbit and human tissue and sequenced. Provided herein is nucleic acid sequence of the beta-8 integrin subunit useful as a diagnostic and in the recombinant preparation of beta-8 integrin subunit and alpha-beta integrin complexes. The beta-8 integrin subunit is used in the preparation and purification of antibodies thereto, and in diagnostic assays.
Claims6
An isolated antibody that specifically binds to beta-8 integrin subunit polypeptide wherein said antibody does not specifically bind to beta integrin subunit polypeptides selected from the group consisting of 1, 2, 3, 4, 5, 6 and 7.
An isolated antibody that specifically binds to a complex comprising a beta-8 integrin subunit polypeptide, which peptide is associated with an alpha v integrin subunit polypeptide wherein said antibody does not specifically bind to a complex comprising an alpha v integrin subunit polypeptide associated with a beta integrin subunit polypeptide selected from the group of beta integrin subunit polypeptides consisting of 1, 2, 3, 4, 5, 6 and 7.
Dependencies are inferred from the claim text.