Gallinacins - antibiotic peptides
AssigneeUniversity of California, Los Angeles
InventorsRobert I. Lehrer, Vladimir N. Kokryakov, Sylvia S. L. Harwig
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Abstract
Peptide-based compounds containing six invariant cysteine residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection in animals and plants. These compounds are of the formulas: ##STR1## wherein each B.sub.i is a basic amino acid and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, either in optionally --SH stabilized linear or in cystine-bridged form.
Claims9
A purified and isolated compound of the formula ##STR8## SEQ ID NO. 1 wherein each B.sub.i represents a basic amino acid, and the N-terminal acylated and C-terminal amidated or esterified forms thereof, which is either in the optionally --SH stabilized linear or in the cystine-bridged form.
A purified and isolated compound of the formula:
- ##STR10## SEQ ID NO. 1 and the N-terminal acylated, C-terminal amidated or esterified forms thereof in either the linearized or the cystine-bridged form
- wherein each B.sub.i is independently a basic amino acid residue at the designated position and wherein said cysteine-bridged compound is isolatable from the neutrophils of an avian subject by a process which comprises subjecting the ultrafiltrate of a lysate of said neutrophils to chromatographic separation techniques to obtain a fraction containing compounds of formula (1) and recovering said compounds of formula (1).
Dependencies are inferred from the claim text.