Bradykinin antagonists
AssigneeCortech, Inc.
InventorsJohn C. Cheronis, James K. Blodgett, Eric T. Whalley, Shadrach R. Eubanks, Lisa G. Allen, Khe T. Nguyen
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Abstract
A brandykinin antagonist of the formula: X(BKA).sub.n wherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonists of the formula X(BKA) are also disclosed. Also disclosed are bradykinin antagonists of the formula: (Y)(X)(BKA) where X and BKA have the meanings indicated above and Y is the peptide chain of an antagonist or agonist for a non-bradykinin receptor.
Claims12
A bradykinin antagonist of the formula:
- BKA.sub.1 -X-BKA.sub.2
- wherein BKA.sub.1 and BKA.sub.2 are the same or different bradykinin antagonist peptides, X is a linking group, linking said peptides via the amino acid residue in the 0, 1, 2, 3, or 5 position of said peptides.
A bradykinin antagonist of the formula:
- X(BKA)
- where BKA is the peptide chain of a bradykinin antagonist peptide and X is a modifying group linked to said peptide via the amino acid residue in the 0, 1, 2, 3 or 5 position of said peptide.
Dependencies are inferred from the claim text.