Stabilized topical pharmaceutical preparations
AssigneeUniversity of Virginia Patent Foundation
InventorsRichard F. Edlich, Sherry Sutton, George T. Rodeheaver
Life of this patent
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Abstract
The present invention relates to stabilized topical pharmaceutical preparations. More specifically the present invention relates to a stabilized topical pharmaceutical preparation, based on the solubilization of a eutectic mixture of local anesthetic agents, in base form, which when combined in the presence of a surfactant and water produce a single phase hydrated polymer to be used in obtaining topical anesthesia and also relates to a stabilized antimicrobial topical pharmaceutical preparation.
Claims10
A phase stabilized pharmaceutical carrier consisting essentially of a major amount of:
- i) a Poloxamer base of a polyoxyethylene-polyoxypropylene condensate of Mn 600-10,000;
- and
- ii) water,
- wherein said pharmaceutical carrier is phase stabilized by subjecting said Poloxamer base and water at a ratio of Poloxamer base to water of from 1:0.8 to 1.2 w/w, to a temperature of from 0.degree. to 10.degree. F.
A phase stabilized pharmaceutical preparation comprising:
- A) a carrier consisting essentially of a major amount of
- i) a Poloxamer base of a polyoxyethylene-polyoxypropylene condensate of Mn 600-10,000;
- ii) water;
- and
- B) a pharmaceutical agent selected from the group consisting of an antibiotic, an anti-fungal and a mixture thereof
- wherein said pharmaceutical preparation is phase stabilized by subjecting said Poloxamer base and water at a ratio of Poloxamer base to water of from 1:0.8 to 1.2 w/w, to a temperature of from 0.degree. to 10.degree. F., prior to addition of said pharmaceutical agent.
Dependencies are inferred from the claim text.