Methods for inducing differentiation of a cell using phenyacetic acid and derivatives
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorDvorit Samid
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Abstract
Compositions and methods of treating anemia, cancer, AIDS, or severe .beta.-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention.
Claims21
A method of inducing the differentiation of a cell comprising administering to the cell a differentiation inducing amount of a compound of the formula I:
- ##STR3## wherein R.sub.0 is aryl, phenoxy, substituted aryl or substituted phenoxy;
- R.sub.1 and R.sub.2 are, independently, H, hydroxy, lower alkoxy, lower straight or branched chain alkyl or halogen;
- R.sub.3 and R.sub.4 are, independently, H, lower alkoxy, lower straight or branched chain alkyl or halogen;
- and
- n is an integer from 0 to 2;
- pharmaceutically-acceptable salt thereof or a mixture thereof.
Dependencies are inferred from the claim text.