Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorDvorit Samid
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Abstract
Compositions and methods of treating anemia, cancer, AIDS, or severe .beta.-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention.
Claims60
A method of treating a neoplastic condition in a subject comprising administering a therapeutic amount of a compound of the formula:
- ##STR3## wherein R.sub.0 is phenyl, naphthyl, phenoxy, substituted phenyl, substituted naphthyl, or substituted phenoxy, wherein the substitution is, independently, from 1 to 4 moieties of
- halogen;
- hydroxy;
- or
- lower straight or branched chain alkyl;
- R.sub.1 and R.sub.2 are, independently, H, hydroxy, lower alkoxy, lower straight and branched chain alkyl or halogen;
- R.sub.3 and R.sub.4 are, independently, H, lower alkoxy, lower straight and branched chain alkyl or halogen;
- and
- n is an integer from 0 to 2;
- or a pharmaceutically-acceptable salt or a mixture thereof.
Dependencies are inferred from the claim text.