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US 5,635,529 AGranted
Sulfonamidodioxepanes, methods of preparation, intermediates, salts and use thereof
AssigneePLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo Zagreb
InventorsMiljenko Dumic, Darko Filic, Mladen Vinkovic, Blanka Jamnicky
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Abstract
Novel O-substituted or O-unsubstituted 6-sulfonamido-1,3-dioxepane-5-ols having hypoglycemic activity are obtained from 6-amino-1,3-dioxepane-5-ol, tetrahydro-6H-[1,3]-dioxepino[5,6-d]oxazole, 5,6-epoxy-1,3-dioxepane or N-sulfonyl-tetrahydro-1H,4H-[1,3]-dioxepino[5,6-b]azirine as starting materials.
Claims20
Compounds of general formula I ##STR7## wherein R.sup.1 and R.sup.2 represent a hydrogen atom, a straight-chain or branched alkyl with 1-4 C atoms or phenyl, or
- R.sup.1 +R.sup.2 together represent alkylidene group with 4-6 C atoms,
- R.sup.3 represents a straight-chain or branched alkyl with 1-4 C atoms, a straight-chain or branched mono- to perfluoroalkyl with 1-4 C atoms, and an o-, m- or p-substituted phenyl group, ##STR8## wherein X represents a hydrogen atom, a lower straight-chain or branched alkyl with 1-4 C atoms, trifluoromethyl group, a halogen atom with atomic number 9-53, hydroxy, alkoxy, amino, alkyl- or dialkylamino, acylamino or hydroxyamino group, and
- Y represents a hydrogen atom, a lower straight-chain or branched alkyl with 1-4 C atoms, benzyl or sulfonyl group
- --SO.sub.2 R.sup.3
- wherein
- R.sup.3 has the above described meanings or represents an acyl group
- --CO--R.sup.4
- wherein
- R.sup.4 represents a lower straight-chain or branched alkyl with 1-4 C atoms, or benzyl group,
- and their physiologically acceptable salts.
7 more elements
Dependencies are inferred from the claim text.