Carboxylic acid compound having condensed ring, salt thereof and pharmaceutical use thereof

A carboxylic acid compound having a condensed ring, which is represented by the formula (I) ##STR75## wherein A is a group of the formula (1) ##STR76## wherein E is hydrogen, alkyl or a protecting group for amidino, guanidino or amino, or a group of the formula (2) ##STR77## wherein E is as defined above;

• B is a group of the formula (3) ##STR78## wherein D is a group of the formula (i) ##STR79## wherein R.sup.5 is hydrogen, alkyl, cycloalkyl or aralkyl, Q is --O--, --S-- --NR.sup.6 --wherein R.sup.6 is hydrogen, alkyl, cycloalkyl, aralkyl, alkylsulfonyl, aralkylsulfonyl, arylsulfonyl, alkanoyl, aralkanoyl, aroyl, heteroarylcarbonyl or --(CH.sub.2).sub.d --COOR.sup.7 wherein R.sup.7 is hydrogen, alkyl, cycloalkyl or aralkyl and d is 1, 2 or 3, G is hydrogen, hydroxy, alkyl, cycloalkyl, phenyl, biphenylyl, pyridyl, aralkyl or E.sup.1 -NR.sup.8 -wherein E.sup.1 is hydrogen, alkyl or a protecting group for amino and R.sup.8 is hydrogen, alkyl, cycloalkyl or aralkyl, p and r are each independently 0 or 1 and q is 0, 1, 2 or 3, provided that when p.noteq.o, at least one of q and r is not O, W is .dbd.CH-- or .dbd.N--, R.sup.3 and R.sup.4 may be the same or different and each hydrogen, alkyl, halogen, alkanoyl, aralkanoyl, aroyl, heteroarylcarbonyl or an alkoxy and e is 1 or 2, or a group of the formula (4) ##STR80## wherein T is --CH<
• or --N<, D is a group of the aforementioned formula (i), provided that when T is --N<, p is 0, R.sup.3 is as defined above and f is 1, 2 or 3;
• L is --O--, --NR.sup.9 -- wherein R.sup.9 is hydrogen, alkyl, cycloalkyl, aralkyl, alkanoyl, aralkanoyl, aroyl, or heteroarylcarbonyl or --S--;
• M is --NR.sup.10 --wherein R.sup.10 is hydrogen, alkyl, cycloalkyl or aralkyl, --O-- or --S--;
• U is .dbd.CH--;
• and
• R.sup.1 and R.sup.2 may be the same or different and each is a hydrogen, a hydroxy, an alkyl, a halogen, an amino, alkanoyl, an aralkanoyl, an aroyl, an heteroarylcarbonyl or an alkoxy,
• or a pharmacologically acceptable salt thereof.