3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them

A 3-amidopyrazole of formula (I):

• ##STR353## in which:
• X and X', together with the carbon atom to which they are linked, form an adamantylidene group;
• R.sub.I represents:
• a phenyl group substituted by R.sub.a, R'.sub.a and R".sub.a, wherein R.sub.a, R'.sub.a and R".sub.a each independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a linear or branched C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a trifluoromethyl group, a trifluoromethoxy group, a nitro group, a carboxyl group or an amino group;
• a tetrahydronaphthyl group;
• or
• a naphthyl group substituted with R.sub.a, R'.sub.a and R".sub.a as defined above;
• R represents hydrogen or linear or branched C.sub.1 -C.sub.4 alkyl group;
• n represents 0, 1, 2 or 3;
• Z represents
• a hydroxyl group;
• a C.sub.1 -C.sub.6 alkoxy group;
• an oxygen atom substituted with a carboxylic acid-protecting group, wherein the carboxylic acid-protecting group is selected from the group consisting of tert-butyl, benzyl, benzyl substituted with a halogen atom, C.sub.1 -C.sub.6 alkyl, trifluoromethyl, trifluoromethoxy or carboxyl group;
• an amino group;
• or
• a nitrogen atom substituted with a carboxyalkyl group in which the alkyl group is a linear or branched C.sub.1 -C.sub.6 group;
• R.sub.IV represents a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.6 alkyl group;
• R.sub.V represents:
• a phenyl group substituted by R.sub.5, R'.sub.5 and R".sub.5, where R.sub.5, R'.sub.5 and R".sub.5 each independently represent a hydrogen atom, a halogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl group, a hydroxyl group, a C.sub.1 -C.sub.4 alkoxy group, a nitro group, a trifluoromethyl group, a trifluoromethoxy group, a cyano group, an amino group, a carboxyl group, a C.sub.1 -C.sub.4 carboxyalkyl group or a phenyl group;
• a styryl group unsubstituted or substituted with a C.sub.1 -C.sub.4 alkyl group;
• or alternatively R.sub.IV and R.sub.V considered together represent:
• a group ##STR354## in which the phenyl group substitutes the pyrazole at position 5 and the group --(CH.sub.2).sub.i -- in which i=1 to 3 substitutes the pyrazole at position 4;
• W.sub.1, W2 and W.sub.3 substitute the benzene ring and independently represent hydrogen, a halogen atom or a hydroxyl group;
• or one of its pharmaceutically acceptable crystallization or separation salts with organic or inorganic acids or with inorganic or organic bases.