Benzimidazole derivatives as angiotensin II receptor antagonists, pharmacticals, and treatment of hypertension therewith

A compound of the formula (I) ##STR37## in which the symbols have the following meaning:

• R(1) is
• 1. (C.sub.1 -C.sub.10)-alkyl
• 2. (C.sub.3 -C.sub.10)-alkenyl,
• 3. (C.sub.3 -C.sub.10)-alkynyl,
• 4. (C.sub.3 -C.sub.8)-cycloalkyl,
• 5. benzyl, or
• 6. benzyl which is substituted on the phenyl moiety by 1 or 2 identical or different substituents selected from the group consisting of halogen, (C.sub.1 -C.sub.4)-alkoxy, and nitro;
• R(2), R(3), R(4) and R(5) are identical or different and are:
• 1. hydrogen,
• 2. hydroxyl,
• 3. halogen,
• 4. a linear or branched (C.sub.1 -C.sub.8)-alkyl radical, unsubstituted or substituted by one are more identical or different substituents selected from the group consisting of halogen, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, (C.sub.1 -C.sub.4)-alkylthio, and mercapto, or
• 5. --CO.sub.2 R(6);
• R(6) is
• 1. hydrogen,
• 2. (C.sub.1 -C.sub.8)-alkyl,
• 3. (C.sub.3 -C.sub.8)-cycloalkyl,
• 4. phenyl,
• 5. benzyl or
• 6. (C.sub.1 -C.sub.8)-alkyl, in which 1 to all of the hydrogen atoms are substituted by fluorine;
• R(15) is
• 1. SO.sub.2 --NR(18)--CO--O--R(17), or
• 2. SO.sub.2 --N(CO--OR(17)).sub.2 ;
• R(16) and (R17) are identical or different and are
• 1. hydrogen,
• 2. (C.sub.1 -C.sub.6)-alkyl,
• 3. (C.sub.3 -C.sub.8)-cycloalkyl,
• 4. (C.sub.6 -C.sub.12)-aryl,
• 5. (C.sub.6 -C.sub.10)-aryl-(C.sub.1 -C.sub.4)-alkyl,
• 6. 2-pyrimidinyl, 1-piperidinyl, or quinuclidinyl,
• 7. (C.sub.3 -C.sub.6)-alkenoyl,
• 8. a radical as defined in 4., 5., 6., 9., 14., 15., 16., 18., 19., or 20. of this subparagraph, substituted by 1 or 2 identical or different substituents selected from the group consisting of hydroxyl, methoxy, nitro, cyano, CO.sub.2 R(6), trifluoromethyl, --NR(25)R(26) and ##STR38##
• 9. (C.sub.1 -C.sub.9)-heteroaryl-(C.sub.1 -C.sub.3)-alkyl, where the heteroaryl moiety is partially hydrogenated, completely hydrogenated, or not hydrogenated,
• 10. (C.sub.1 -C.sub.6)-alkyl, in which 1 to all of the hydrogen atoms are substituted by fluorine,
• 11. (C.sub.2 -C.sub.6)-alkenyl,
• 12. (C.sub.3 -C.sub.8)-cycloalkenyl,
• 13. (C.sub.3 -C.sub.8)-cycloalkenyl-(C.sub.1 -C.sub.13)-alkyl,
• 14. (C.sub.3 -C.sub.8)-cycloalkyl-(C.sub.1 --C.sub.4)-alkyl,
• 15. (C.sub.6 -C.sub.10)-aryl-(C.sub.3 -C.sub.8)-alkenyl,
• 16. (C.sub.1 -C.sub.9)-heteroaryl-(C.sub.3 -C.sub.6)-alkenyl,
• 17. (C.sub.3 -C.sub.6)-alkynyl,
• 18. (C.sub.6 -C.sub.10)-aryl-(C.sub.3 -C.sub.6)-alkynyl,
• 19. (C.sub.1 -C.sub.9)-heteroaryl-(C.sub.3 -C.sub.6)-alkynyl,
• 20. a radical of the formula ##STR39## where R(16) cannot have the meaning of 20. of this subparagraph (stereocenters are present either in the R- or in the S-configuration), or
• 21. R(16)R(17), together with the nitrogen atom bearing them, form a heteroaryl radical which is partially hydrogenated, completely hydrogenated, or not hydrogenated;
• R(18) is
• 1. hydrogen
• 2. (C.sub.1 -C.sub.6)-alkyl,
• 3. (C.sub.3 -C.sub.8)-cycloalkyl,
• 4. (C.sub.6 -C.sub.12) -aryl-(C.sub.1 -C.sub.6)-alkyl,
• 5. phenyl, or
• 6. (C.sub.1 -C.sub.9)-heteroaryl;
• D is NR(23), O or CH.sub.2 ;
• q is zero or 1;
• R(23) is hydrogen, halogen, (C.sub.1 --C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy;
• R(25) and R(26) are identical or different and are
• 1. hydrogen,
• 2. (C.sub.1 -C.sub.4)-alkyl
• 3. phenyl,
• 4. benzyl or
• 5. .alpha.-methylbenzyl;
• or a physiologically tolerable salt thereof.