Substituted oxazolidines
AssigneeCiba-Geigy Corporation
InventorsAlfred Sallmann, Hans-Peter Gschwind, Eric Francotte
Life of this patent
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Abstract
The invention relates to novel substituted oxazolidines of formula (I) wherein R.sub.1 and R.sub.2 are simultaneously hydrogen or both together are the identical lower alkyl radical, and to the salts thereof in racemic and chiral form, to a process for the preparation of said compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments. The compounds have a stimulating effect on beta-adrenergic receptors and can be used, inter alia, for the treatment of diseases associated with reversible obstruction of the respiratory tract, typically asthma and chronic bronchitis, and also for inflammation of different origin.
Claims12
A compound of formula ##STR5## wherein R.sub.1 and R.sub.2 are simultaneously hydrogen or both together are the identical alkyl radical of up to seven carbon atoms, or a salt thereof in racemic and chiral form.
The racemate of (5R)-3-[6-(4-phenylbutoxy)hexyl]-5-(4-hydroxy-3-hydroxymethylphenyl)oxazol idine and (5S)-3-[6-(4-phenylbutoxy)hexyl]-5-(4-hydroxy-3-hydroxymethylphenyl)oxazol idine, or a pharmaceutically acceptable salt thereof.
(5R)-3-[6-(4-phenylbutoxy)hexyl]-5-(4-hydroxy-3-hy droxymethylphenyl)oxazolidine, or a pharmaceutically acceptable salt thereof.
(5S)-3 -[6-(4-phenylbutoxy)hexyl]-5-(4-hydroxy-3-hydroxymethylphenyl)oxazolidine, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.