Immunosuppressive agents
AssigneeThe University of Sheffield
InventorsDavid N. Jones, John L. Maddocks
Life of this patent
Estimating the term…
Abstract
A suppression of the human immune system is accomplished by administering to the person an effective amount of a non-toxic thioheterocycle compound having the formula ##STR1## wherein R1 is a heterocycle ring system, R2 is a hydrogen, alkyl or aryl group, and R3 is a hydrogen, alkyl, aryl or nitroaryl group.
Claims4
A method of suppressing the immune system of a human comprising administering to a person requiring the same an effective amount of a compound of the following formula:
- ##STR33## in which R.sup.1 is a heterocyclic ring system selected from the group consisting of:
- ##STR34## in which R.sup.4 is hydrogen or methyl or ethyl or propyl or phenyl or 1-naphthyl, ##STR35## in which R.sup.5 is hydrogen or trifluoromethyl or phenyl or 4-chlorophenyl or 4-methoxyphenyl or 3-pyridyl, ##STR36## in which R.sup.6 is hydrogen or phenyl or chlorophenyl or 4-methoxyphenl, ##STR37## in which R.sup.11 is hydrogen, methyl, or hydroxyl;
- and
- R.sup.12 is hydrogen or methyl;
- and
- X is nitrogen or C--H, ##STR38## in which Z is oxygen or sulphur or N--H;
- and
- Y is C--H or nitrogen, and ##STR39## R.sup.2 is a hydrogen, alkyl or aryl;
- and R.sup.3 is a hydrogen, alkyl, aryl or nitroaryl.
A method as claimed in 1 in which R.sup.2 is hydrogen, methyl, ethyl or propyl;
- and R.sup.3 is hydrogen, methyl or 4-nitrophenyl.
A method of suppressing the immune system of a human comprising administering to a person requiring the same an effective amount of a compound having the following formula:
- ##STR40## in which R.sup.2 is hydrogen, or methyl or ethyl or propyl, and
- R.sup.3 is hydrogen or methyl or 4-nitrophenyl,
- and in which R.sup.1 may be one of the following ##STR41## in which R.sup.10 is hydrogen or an alkoxy group;
- and
- R.sup.7 is hydrogen, alkyl, nitro, halide or an alkoxy group;
- and
- R.sup.8 is hydrogen, halide or an alkoxy group;
- and
- R.sup.9 is hydrogen or an alkoxy group or ##STR42## in which Z is oxygen or sulphur or N--H;
- and Y is C--H or nitrogen or ##STR43##
A compound comprising the following formula:
- ##STR44## wherein the molecular groups R.sup.1, R.sup.2, and R.sup.3 are defined as one of the following:
- R.sup.1 is defined as the following:
- ##STR45## in which R.sup.2 is methyl;
- and
- R.sup.3 is hydrogen;
- and
- R.sup.7, R.sup.8, R.sup.9, R.sup.10 are one of the following combinations;
- R.sup.9 and R.sup.10 are both hydrogen, and R.sup.7 and R.sup.8 are both methoxy groups;
- or
- R.sup.8, R.sup.9, R.sup.10 are all hydrogen and R.sup.7 is methyl;
- or
- R.sup.8, R.sup.9, R.sup.10 are all hydrogen and R.sup.7 is a nitro group;
- or
- R.sup.9 and R.sup.10 are both hydrogen, R.sup.7 is fluorine, and R.sup.8 is chlorine;
- or
- R.sup.7 and R.sup.8 are both hydrogen and R.sup.9 and R.sup.10 are both methoxy groups or
- R.sup.1 is defined as the following:
- ##STR46## in which R.sup.2 is methyl;
- and
- R.sup.3 is hydrogen;
- and
- Y and Z are defined as one of the following combinations;
- Y is C--H and Z is oxygen;
- or
- Y is nitrogen and Z is sulphur;
- or
- Y is nitrogen and Z is N--H.
Dependencies are inferred from the claim text.