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US 5,635,520 AGranted
Anti-ulcer compositions suitable for rectal administration
AssigneeTakeda Chemical Industries, Ltd.
InventorYoshiaki Uda
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AssigneeTakeda Chemical Industries, Ltd.
InventorYoshiaki Uda
Estimating the term…
The present invention relates to a composition for rectal administration which comprises a benzimidazole compound having antiulcer activity and a salt of C.sub.6-20 fatty acid, both of which are intermingled with each other in a base for rectal administration. The composition for rectal administration of the present invention is effective for the treatment of gastrointestinal ulcers, is excellent in the stability of the active ingredient therein and the absorption thereof to thereby insure an early attainment of therapeutically effective blood concentration and permits control of the rate of absorption of the drug. Furthermore, the composition for rectal administration of the present invention swells in the intestinal tract, attaches itself to the mucosa, and releases the active ingredient gradually over a long time to supply the drug at a high concentration and with high efficiency. Therefore, the expected therapeutic efficacy can be obtained at a low dosage level with a minimum of side effect.
A composition suitable for providing an anti-ulcer effect and suitable for rectal administration which comprises 2-(2-(3-methyl-4-(2,2,2-trifluoroethoxy)pyridyl) methylsulfinyl)-benzimidazole or a physiologically acceptable salt thereof and a salt of a fatty acid having 6 to 20 carbon atoms in an amount effective to stabilize 2-(2-(3-methyl-4-(2,2,2-trifluoroethoxy)-pyridyl)methylsulfinyl)benzimidaz ole, said salt and 2-(2-(3-methyl-4-(2,2,2-trifluoroethoxy)pyridyl) methylsulfinyl)-benzimidazole being intermingled in a base suitable for said rectal administration;
In a composition suitable of the delivery of 2-(2-(3-methyl-4-(2,2,2-trifluoroethoxy)pyridyl) methylsulfinyl)-benzimidazole to a patient to provide an anti-ulcer effect, the improvement which comprises 2-(2-(3-methyl-4-(2,2,2-trifluoroethoxy)pyridyl) methylsulfinyl) benzimidazole or a physiologically acceptable salt thereof in a base suitable for rectal administration, said base including a salt of a fatty acid having 6 to 20 carbon atoms in an amount effective to stabilize 2-(2-(3-methyl-4-(2,2,2-trifluoroethoxy)pyridyl)methylsulfinyl)-benzimidaz ole, said salt and 2-(2-(3-methyl-4-(2,2,2-trifluoroethoxy)pyridyl) methylsulfinyl]benzimidazole being intermingled in said base;
Dependencies are inferred from the claim text.