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US 5,635,519 AGranted
Benzothiazole compounds which are substituted by pyridymethyl
AssigneeEisai Co., Ltd.
InventorsYasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu
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Abstract
A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##
Claims20
A benzothiazole compound represented by the following formula (I):
- ##STR69## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or a lower alkoxy group, R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a group represented by the formula:
- ##STR70## wherein q is an integer of from 1 to 4, or a group represented by the formula:
- ##STR71## wherein R.sup.7 represents a lower alkyl group;
- R.sup.4 represents a hydrogen atom, a lower alkyl group, a phenyl group, a group represented by the formula:
- ##STR72## wherein q is an integer of from 1 to 4, or a group represented by the formula:
- ##STR73## wherein R.sup.7 represents a lower alkyl group;
- and one of R.sup.3 or R.sup.4 is either ##STR74## R.sup.2 represents a hydrogen atom or a protective group of a hydroxyl group;
- and
- R.sup.5 and R.sup.6 are either same or different and each represents a hydrogen atom, a lower alkyl group, an acyl group or a group represented by the formula:
- ##STR75## wherein r is an integer of from 1 to 4;
- wherein when R.sup.4 is ##STR76## then at least one of R.sup.5 and R.sup.6 is ##STR77## or an acyl group, or a pharmacologically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.