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US 5,635,516 AGranted
(Thia) cycloalkyl[B]indole compounds as anti-inflammatory agents
AssigneeAdir et Compagnie
InventorsPaul Caubere, Brigitte Jamart-Gregoire, Catherine Caubere, Dominique Manechez, Pierre Renard, Gerard Adam, Catherine Nguyen
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Abstract
A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description.
Claims11
A compound selected those of formula (I):
- ##STR28## in which:
- R.sub.1 represents Ar--(CH.sub.2).sub.n --O-- wherein n represents zero or 1 to 4 inclusive and Ar is selected pyridyl, quinolyl, isoquinolyl, Ar being unsubstituted or substituted by one or more radicals selected from halogen, alkyl, alkoxy, hydroxy and trifluoromethyl;
- R.sub.3 is selected from carboxyalkyl and alkoxycarbonylalkyl;
- and
- A represents --(CH2)m-- wherein m is 3-6 inclusive, or represents a group of formula (.alpha.):
- ##STR29## in which p is 1-4 inclusive;
- wherein the terms "alkyl" and "alkoxy" denote linear or branched groups having 1 to 6 carbon atoms inclusive,
- their optical isomers, in pure form or in the form of a mixture,
- and their pharmaceutically-acceptable addition salts with an acid or a base.
6 more elements
Dependencies are inferred from the claim text.