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AssigneesSenju Pharmaceutical Co., Ltd., The Green Cross Corporation
InventorsTakahiro Kumonaka, Takema Hase, Tomoji Aotsuka, Toshio Kurihara, Yoshiyuki Nakamura, Tetsuo Matsui, Hiromichi Ishikawa, Fujio Kobayashi
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A 1,4-benzoxazine-2-acetic acid compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, a method for production thereof, and a pharmaceutical composition, an aldose reductase inhibitor and an agent for the prevention and/or treatment of the complications of diabetes, which contain the same. The compound (I) of the present invention and pharmaceutically acceptable salts thereof have aldose reductase inhibitory action and are superior in safety. Accordingly, they are useful as an agent for the prevention and/or treatment of the complications of diabetes such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis.
A 1,4-benzoxazine-2-acetic acid compound of the formula (I) ##STR19## wherein R.sup.1, R.sup.2 and R.sup.3 may be the same or different and each is a hydrogen atom, a lower alkyl, an alkoxy, a halogen atom or a hydroxy, R.sup.4 is a hydrogen atom, a halogen atom, a lower alkyl or an alkoxy, and R.sup.5 is an optionally esterified carboxyl, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.