Methods of prevention of oral mucositis with transforming growth factor .beta.
AssigneeOncogene Science, Inc.
InventorJohn D. Haley
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Abstract
The present invention provides methods of preventing oral mucositis in a subject susceptible to mucositis which comprises administering to the subject a prophylactically effective amount of TGF-.beta.3. Typically, administration is topical and initiated prior to anti-neoplastic therapy such as radiation treatment or chemotherapy. The invention is particularly suited for pediatric patients.
Claims9
A method of preventing chemotherapy or radiation therapy induced oral mucositis in a subject which comprises administering to the subject a composition consisting essentially of a prophylactically effective amount of TGF-.beta.3, said administration to the subject being commenced at least 24 hours prior and not more than five days prior to a given cycle of chemotherapy or radiation therapy and not continuing for more than five days during such cycle nor continuing after cessation of such cycle of chemotherapy or radiation therapy.
Dependencies are inferred from the claim text.