Amphipathic, micellar delivery systems for biologically active polyions
OwnerJon A. Wolff, Vladimir Budker +1inventors
InventorsJon A. Wolff, Vladimir Budker, Vladimir Gurevich
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Abstract
The present invention provides a composition comprising a population of micelles wherein each micelle comprises at least one amphipathic compound layer that surrounds a non-aqueous core that contains a polyion. Also provided are a method of preparing such a composition and the uses of such compositions for delivering biologically active polyions to cells.
Claims5
A composition comprising a population of micelles wherein each micelle comprises at least one amphipathic compound layer that surrounds a non-aqueous core that contains a polyion, wherein the amphipathic compound has the structure:
- ##STR28##
A process of preparing a population of mixed micelles comprising mixing an amphipathic compound with a polyion in an aqueous solution containing at least fifty volumes percent of a water-soluble organic solvent to form the micelles.
A process of preparing a population of mixed micelles comprising mixing an amphipathic compound with a polyion in an aqueous solution containing at least fifty volumes percent of a water-soluble organic solvent to form the micelles;
- and mixing the micelles with a second amphipathic compound to form an admixture and decreasing the concentration of the water-soluble organic solvent in the admixture.
A process of preparing a population of mixed micelles comprising mixing an amphipathic compound with a polyion in an aqueous solution containing at least fifty volumes percent of a water-soluble organic solvent to form the micelles, wherein the amphipathic compound has the structure:
- ##STR29##
Dependencies are inferred from the claim text.