Propionibacteria peptide microcin
AssigneeState of Oregon acting by and through the Oregon State Board of Higher Education on behalf of Oregon State University
InventorsJames W. Ayres, William E. Sandine, George H. Weber
Life of this patent
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Abstract
A peptide, produced by propionibacteria, has a molecular weight of between 300 and 1200 daltons and is inhibitory to gram-negative bacteria. The peptide can be produced by purification of a propionibacteria metabolite mixture, by chemical synthesis, or by a host transformed with a recombinant vector, and is useful in preventing and treating bacterial infections.
Claims10
A composition useful for inhibiting the growth of gram-negative bacteria, said composition consisting essentially of a peptide produced by Propionibacterium shermanii, the peptide being of molecular weight between 300 daltons and 1200 daltons and comprising the amino acids metbiotite and valine and having an activity of inhibiting the growth of gram-negative bacteria.
A peptide isolated from Propionibacterium shermanii, the peptide being of molecular weight between 800 and 1200 daltons and comprising the amino acids metbiotite, valine and glycine, and being inhibitory to the growth of gram-negative bacteria.
A composition having an activity of inhibiting the growth of gram-negative bacteria, said composition consisting essentially of a peptide produced by Propionibacterium shermanii, the peptide being of molecular weight between 800 and 1200 daltons and comprising the amino acids methionine, valine.
Dependencies are inferred from the claim text.