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US 5,635,482 AGranted
Synthetic compounds and compositions with enhanced cell binding
AssigneeThe Regents of the University of California
InventorRajendra S. Bhatnagar
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Abstract
Compositions of the invention include composites comprising a biomaterial having compounds thereon with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction and for in vitro uses. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docking of collagen binding species (such as cell surface receptors for collagen and fibronectin) and have the amino acid residues -Ile-Ala- folded in a .beta.-bend.
Claims8
An implant comprising:
- a matrix formed of a biomaterial and a peptide carried by the matrix, the peptide having enhanced cell binding with respect to collagen, the peptide having a domain that mimics collagen binding to cells, said domain including at least -Ile-Ala- folded in a .beta.-bend at physiologic conditions, wherein the peptide has the sequence Gly-Thr-Pro-Gly-Pro-Gln-Gly-Ile-Ala-Gly-Gln-Arg-Gly-Val-Val (SEQ ID NO:
- 1), Gly-Pro-Gln-Gly-Ile-Ala-Gly-Gln-Arg (SEQ ID NO:
- 2), Gln-Gly-Ile-Ala-Gly-Gln (SEQ ID NO:
- 3), Gln-Gly-Ile-Ala-Gly-Gln-Arg (SEQ ID NO:
- 4), Phe-Gly-Ile-Ala-Gly-Phe (SEQ ID NO:
- 5), Gly-Ile-Ala-Gly-Gln (SEQ ID NO:
- 6), Gln-Gly-Ala-Ile-Ala-Gln (SEQ ID NO:
- 7), Phe-Gly-Ile-Ala-Gly-Phe (SEQ ID NO:9), Cys-Gly-Ile-Ala-Gly-Cys (SEQ ID NO:10), Glu-Gly-Ile-Ala-Gly-Lys (SEQ ID NO:11), NAc-Ile-Ala-Ala (SEQ ID NO:12), Ile-Ala-.beta.Ala (SEQ ID NO:13), and NAc-Ile-Ala-N-Me (SEQ ID NO:14).
5 more elements
Dependencies are inferred from the claim text.