Use of calcitonin gene-related peptide to regulate immune response
AssigneeYale University
InventorAgnes M.-C. Vignery
Life of this patent
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Abstract
Calcitonin gene-related peptide regulate immune cell function and cytokine release and are useful in the treatment of immune cell and cytokine mediated, immune mediated diseases, such as rheumatoid arthritis, treating viral infections, tumors and organ transplants.
Claims9
A method of down-regulating the immune response in a human being suffering from an inflammatory condition mediated by a hyperimmune response resulting from cytokine release and receptor expression by immune and non-immune cells, interleukin1 (IL-1) or IL-1 and interleukin-2 (IL-2) release from interleukin-1 and interleukin-2 releasing cells, which comprises administering thereto an immunosuppressive amount of calcitonin gene-related peptide (CGRP) effective to down-regulate the immune response and ameliorate the inflammatory condition.
A sterile pharmaceutical composition adapted for systemic administration by injection which comprises per unit dosage an IL-1 release inhibiting amount of CGRP from 10 to 100 mg per unit dosage, in admixture with a pharmaceutically acceptable carrier.
A method of treating diabetes which comprises administering to a human being suffering from the disease an immunosuppressive amount of calcitonin gene-related peptide (CGRP) effective to ameliorate the disease.
Dependencies are inferred from the claim text.