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AssigneeApplied Research Systems ARS Holding N.V.
InventorsScott C. Chappel, Edward G. Bernstine
Estimating the term…
Described are new glycoprotein hormones capable of competing with natural hormones for the normal receptor binding sites but substantially incapable of effecting post receptor activities. The glycoprotein hormones of the present invention have had specific (rather than all) oligosaccharide chains removed so as to effectively diminish biologic activity while not significantly reducing plasma half-life, thus improving the molecules effectiveness as an antagonist compared with conventionally-produced molecules. The preferred glycoprotein hormones are ideally obtained by site-directed mutagenesis to selectively deglycosylate the protein. Also described are therapeutic treatments comprising the administration of the recombinant glycoprotein hormones of the present invention as hormone antagonists.
A method for effecting a first trimester abortion comprising administering a therapeutically effective dose of a recombinant human chorionic gonadotropin capable of competing with natural human chorionic gonadotropin for receptor binding but incapable of stimulating post receptor biologic activity, and having a plasma half-life approximately equal to that of natural human chorionic gonadotropin, wherein said recombinant human chorionic gonadotropin has at least one N-linked oligosaccharide chain entirely removed.
Dependencies are inferred from the claim text.